Today · latest update 4:22 PM · Monday, October 19, 2026
Today's updates
Commodities
· Updated 4:22 PM
Energy Secretary Chris Wright said on Monday the administration is allowing sanctioned oil tankers a process to start legitimately shipping crude, extending the sanctions easing that President Trump defended on Sunday as a negotiating step in the Russia-Ukraine talks.
Politics
· Updated 4:02 PM
The United States on Monday announced the successful resolution of a USMCA rapid response labor case at the Alimentos Grole facility in Ciudad Obregon, Sonora, after the company reinstated nine dismissed workers and disbanded a company-aligned internal labor committee.
Rates
· Updated 3:29 PM
The Securities and Exchange Commission will host a roundtable on November 9 on the use of machine-understandable data and superintelligence, and the risks and costs that come with them.
Infrastructure
· Updated 3:09 PM
The Department of War said on Monday it has signed a framework agreement with BAE Systems to buy up to 25,000 APKWS guidance kits a year for up to seven years, pending congressional authorization and funding.
Technology
· Updated 3:09 PM
AI chip startup Tenstorrent has raised 1.5 billion dollars at a 6.2 billion dollar valuation, more than double its late 2024 valuation, and will use the capital to scale chips for serving open-weight AI models.
Commodities
· Updated 3:02 PM
Brent rose back above 110 dollars a barrel on Monday afternoon, at 110.53 dollars in market data updated at 2:02pm ET, after falling to 107.57 dollars in Asian trading on expectations that the US waiver of Russia sanctions could bring more fuel supply.
Politics
· Updated 2:51 PM
Treasury's FinCEN said on Monday it has identified about 270 million dollars in suspicious financial activity potentially linked to fraud against federal student aid programs and referred the findings to federal investigators.
Life Sciences
· Updated 2:51 PM
The FDA granted accelerated approval on Monday to GSK's Jemperli used alone for adults with previously untreated stage II or III locally advanced rectal cancer whose tumours are dMMR or MSI-H.
Mining
· Updated 1:27 PM
The Interior Department's Marine Minerals Administration issued its final leasing notice on Monday for the first US offshore mineral lease sale, covering about 31.5 million acres near American Samoa with an auction on November 19.
Infrastructure
· Updated 1:27 PM
The Competition and Markets Authority delivered its Phase 1 report on BT's completed acquisition of TalkTalk and PlatformX to the Secretary of State on Monday, ahead of the 5pm deadline.
Infrastructure
· Updated 1:27 PM
American Electric Power, Amazon and X-energy announced on Monday they are exploring a 960 MW advanced nuclear project of 12 Xe-100 small modular reactors at a former coal plant site in Sullivan County, Indiana.
Life Sciences
· Updated 11:19 AM
Merck KGaA of Darmstadt said on Monday that it has agreed to buy London based Silence Therapeutics for 20 dollars per American depositary share in cash, an equity value of about 1.3 billion dollars, adding the phase 3 ready siRNA therapy divesiran to its rare disease pipeline.
Politics
· Updated 11:07 AM
The Office of Foreign Assets Control on Monday added five Chinese entities to its Non-SDN Menu-Based Sanctions List under the Protecting American Intellectual Property Act of 2022, including the Beijing venture firm MiraclePlus and its two renminbi funds.
Technology
· Updated 9:54 AM
Elon Musk said on Monday that he will give every child in the United States one of his shares in SpaceX next year, a pledge worth about 10.5 billion dollars at Friday's closing price if it covered all 72 million Americans under 18.
Commodities
· Updated 9:49 AM
Hybrid electric vehicles reached 16 percent of United States light-duty vehicle sales in the third quarter of 2026, while battery electric vehicles fell to 6 percent from 10 percent a year earlier, the Energy Information Administration said on Monday.
Infrastructure
· Updated 9:49 AM
The Competition and Markets Authority on Monday dismissed an appeal by RWE companies and confirmed the Gas and Electricity Markets Authority decision of May 1, 2026 to reject modification CMP344 to the Connection and Use of System Code.
Infrastructure
· Updated 8:44 AM
Alcoa has agreed to sell portions of its former Massena East aluminum smelter in upstate New York to an unnamed data center firm for up to $315 million, with $50 million to $65 million due at closing.
Infrastructure
· Updated 7:17 AM
JPMorgan Chase has deployed 5 billion dollars in direct startup investments in the first year of its United States security and resiliency initiative, halfway to its 10 billion dollar goal for the decade, CNBC reported on Monday.
Rates
· Updated 7:11 AM
The Reserve Bank of India allotted Rs 1,00,014 crore in a seven-day variable rate repo on Monday at a cut-off of 5.51 percent, drawing bids of Rs 1,50,735 crore against Rs 1,00,000 crore notified.
Mining
· Updated 7:10 AM
New Hope Corporation agreed to acquire the roughly 74 percent of Malabar Resources it does not already own in an all-scrip scheme valuing Malabar's equity at about 1.8 billion Australian dollars, and its shares rose 4.6 percent to 6.11 Australian dollars on Monday.
Commodities
· Updated 6:44 AM
Qatar's deputy prime minister, Sheikh Saoud bin Abdulrahman Al Thani, warned at the Global Security Forum in Doha on Monday that the global energy shockwaves from the war on Iran have yet to reach their peak, with further repercussions expected in the coming days and months.
Technology
· Updated 6:44 AM
A drone attack targeted a data center operated by Russian technology firm VK in the Leningrad region near St Petersburg, the company said, while internet monitor NetBlocks recorded a 44 percent drop in VK network activity over the weekend.
Infrastructure
· Updated 6:44 AM
The European Commission sent KKR a Statement of Objections on Monday, saying its preliminary view is that KKR, at least negligently, gave incorrect or misleading information about FiberCop's long-term wholesale access agreements during the 2024 review of its acquisition of Telecom Italia's NetCo network business.
Politics
· Updated 4:44 AM
The Philippines summoned China's ambassador on Monday to protest remarks that Manila said conveyed a threat of the use of force, after the envoy told reporters China may easily win a confrontation but would not use force because it loves peace.
Politics
· Updated 3:45 AM
The World Food Programme said on Monday it is ending monthly assistance to 500,000 people in Gaza because of a funding shortfall, cutting the number it helps from 1.6 million to 1.1 million, about half the territory's population.
Commodities
· Updated 3:45 AM
Two Greenpeace activists were charged with interfering with an offshore petroleum installation after a weekend occupation of Woodside Energy's Scarborough floating production unit off Western Australia forced the company to suspend pre-commissioning work.
What matters today
Rates
People's Bank of China Governor Pan Gongsheng told the Financial Street Forum on Monday that the central bank will study switching its main policy rate from the seven-day reverse repo to the overnight rate, and announced a new liquidity support tool for non-bank institutions facing large redemptions.
Why it matters: China is rebuilding its monetary framework around an overnight rate, the convention used by the Federal Reserve and other major central banks, while adding a standing backstop against bond fund redemption spirals, a package that changes how Chinese rates are set and defended without moving the loan prime rate that markets expect to stay on hold on Tuesday.
Infrastructure
Nscale, the Nvidia backed data centre developer preparing a United States listing, faces investor pressure to cut its roughly 30 billion dollar IPO valuation target to between 16 billion and 19 billion dollars after a run of setbacks for artificial intelligence infrastructure companies.
Why it matters: The pushback is the clearest sign yet that public investors are repricing the neocloud model, where contracted demand runs far ahead of powered, operating capacity, and it lands weeks after Microsoft walked away from Nscale's only British data centre.
Infrastructure
TAL Daiichi Life Australia has made a non-binding indicative offer of A$11.80 per share for the 79.5 percent of Challenger it does not already own, valuing Australia's largest annuity provider at about A$7.94 billion (5.53 billion dollars), and Challenger shares jumped 16.7 percent to an eight-year high of A$11.49 on Monday.
Why it matters: Full ownership would put the retirement incomes of a growing share of Australians under a Japanese life insurer, and the bid prices Challenger's annuity book on the strength of a 52 percent jump in quarterly annuity sales.
Technology
Microsoft has signed a 20 year agreement with NiSource under which the utility will add about 1.1 gigawatts of generation for its planned northern Indiana data center campus, with service starting in 2028 and Microsoft funding the required infrastructure.
Why it matters: The deal is a concrete test of the large load rate model in which a hyperscaler pays for the generation and transmission its campus needs, and NiSource says it lifts expected savings for existing customers to about 1.75 billion dollars over the life of its data center contracts.
Life Sciences
Nouscom has closed an oversubscribed 120 million euro ($135 million) Series D to fund a global registration enabling trial of NOUS-209, its off the shelf vaccine designed to intercept cancer in people with Lynch syndrome.
Why it matters: Cancer prevention vaccines have repeatedly failed to reach pivotal testing, so a nine figure round behind a registration enabling trial in a defined hereditary population is a real test of whether interception can become a drug category rather than a concept.
Politics
China's commerce and science ministries proposed export prohibitions or restrictions on 12 solar manufacturing technologies on October 16, covering polysilicon, thin wafers, perovskite and tandem cells, with public consultation open until November 15.
Why it matters: The draft would extend Beijing's technology controls from finished goods to the factory know-how behind them, complicating United States and Indian plans to build solar manufacturing that does not depend on Chinese process technology.
Rates
Traders pared the implied probability of a Federal Reserve rate increase at the October 27 to 28 meeting to less than one in five, and in one account less than one in six, after remarks by Chair Kevin Warsh in Bangkok were read as supporting a hold, Bloomberg reported on Monday.
Why it matters: The repricing unwinds the hike premium built after last week's hot United States inflation print, halts the dollar's gains and leaves December, not October, as the live meeting for the next move.
Mining
Workers at Antofagasta's Centinela copper mine in Chile have ratified a new collective agreement by 94.49 percent, ending a strike by more than 700 union members that began on October 7.
Why it matters: The settlement removes one of the two Chilean strike risks that had been supporting copper prices, and Antofagasta says production ran at normal levels throughout, so no supply was lost.
Markets today · Monday, October 19, 2026 · Updated 12:50 PM
The chip complex that led Friday's selloff is leading Monday's rebound, with Amazon up 5.10 percent, Tesla up 4.00 percent and semiconductors up 2.89 percent by midday, while WTI crude fell 2.67 percent to 98.70 dollars as the sanctions waiver kept pressure on oil.
Amazon rose 5.10 percent to 262.74 dollars, the largest move in the midday tables. No story in today’s reporting explains the rise: the only Amazon mention in today’s files is the Linux KVM story on the technology beat, which reported that Amazon Web Services says its cloud is not at risk from the hypervisor flaw, and that is not presented there as a share price catalyst.
Tesla rose 4.00 percent to 368.92 dollars. No story in today’s reporting explains that move either: today’s only Tesla reference is in the China solar export controls story on the commodities beat, which named Tesla among United States firms whose solar expansion plans the proposed controls could affect, a potential headwind rather than a reason to buy.
The semiconductor index rose 2.89 percent to 507.67 dollars, Broadcom rose 2.73 percent to 337.72 dollars and Nvidia rose 1.84 percent to 218.07 dollars, reversing part of Friday’s falls of 4.14 percent for the index and 4.52 percent for Broadcom. Today’s Kospi story is the linked reporting: Seoul opened down 3.17 percent but pared the loss to 1.36 percent in early trade as foreign and institutional buyers stepped in, the first Asian read that Friday’s selloff was stabilising, and the midday New York figures follow that pattern rather than breaking it. No story in today’s files gives a company specific cause for the rebound. The counterweight in today’s reporting is the Nscale story on the infra-deals beat, where investors are pressing the Nvidia backed developer to cut its IPO valuation target from about 30 billion dollars to between 16 billion and 19 billion dollars, evidence that private AI infrastructure valuations are still being marked down even as listed chips recover.
WTI crude fell 2.67 percent to 98.70 dollars a barrel, while Brent was nearly flat, down 0.36 percent at 109.46 dollars. Today’s oil story on the commodities beat explains the direction: oil slipped from a five month high after President Trump waived Russia sanctions, raising hopes of more Russian fuel supply, and traders took profits, even though Gulf crude flows through Hormuz averaged about 8.5 million barrels a day last week against more than 20 million the week before. The midday split between the two benchmarks, WTI down sharply and Brent steady, is in the tables but is not explained by any story in today’s reporting.
Dry bulk freight rose 3.19 percent to 12.95 dollars, the third largest move in the tables, while tanker freight fell 1.79 percent. No story in today’s reporting explains either freight move.
The cross-market read is a selective risk-on, confined to the United States technology complex. The Nasdaq 100 rose 1.58 percent and the S and P 500 rose 0.61 percent, but European benchmarks fell, the FTSE 100 down 1.08 percent and the DAX down 1.18 percent, Treasury yields backed up, with the United States 10 year up 4.8 basis points to 5.15 percent, and gold fell 0.45 percent to 4,162.20 dollars with the dollar index nearly flat. A broad relief rally would have lifted Europe and pushed yields and gold the other way; instead, Monday midday looks like buyers returning to the specific names sold hardest on Friday, at yields that remain above 5 percent.
Commodities
Chicago wheat rose as much as 0.8 percent on Monday and was up 0.6 percent at 6.645 dollars a bushel in Singapore trading, after weekend strikes between Russia and Ukraine made a restart of Black Sea exports from the two producers look less likely.
Ukraine is in talks with Turkey, Egypt and India on opening Black Sea civil navigation for food exports, President Zelenskyy said, with Kyiv able to export only 38 percent of regular volumes since shipments halted in August and Russia opposing the plan.
A 50 year old Ukrainian army officer identified as Serhii K. went on trial in Hamburg on Monday accused of committing a war crime by leading the 2022 sabotage of the Nord Stream gas pipelines, with prosecutors saying he had a mandate from Ukrainian authorities.
Japan's nationwide average power price rose more than 25 percent week on week to 31.15 yen, or 0.19 dollars, per kilowatt hour on Monday, as spot LNG for December delivery into north east Asia reached 29.30 dollars per million British thermal units, its highest since December 2022.
India paid 15.4 billion dollars to import crude oil in September, up 46 percent from 10.5 billion dollars a year earlier, as the Indian crude basket averaged 116.09 dollars a barrel and import volumes rose only 7 percent.
Global food inflation is poised to accelerate in the coming months and persist well into 2027, Reuters reported, with the FAO Food Price Index averaging 136 points in September, its highest since November 2022, and food prices outpacing headline inflation in 22 percent of the 150 countries the World Bank analysed.
Copper traders are growing wary of the bull market as the expected US tariff decision on refined copper remains missing, with US stocks on and off exchange now estimated by Macquarie at about 1.6 million tons and the Comex to London arbitrage down to about 310 dollars a ton.
Goldman Sachs expects Brent at 90 dollars in December and an 80 dollar average in 2027 as Middle East supply recovers, the European Commission put the EU renewable share at 26.2 percent in 2025 against a 42.5 percent 2030 target, and Egypt is shifting power plants from gas toward fuel oil at roughly half the cost.
Mining
South32 reported September quarter payable copper production of 18,700 tonnes from its Sierra Gorda share, up 2 percent year on year but below the 19,200 tonne Visible Alpha consensus, and its shares closed 2.59 percent lower at 4.51 Australian dollars.
Core Lithium cut 92 metres at 1.25 percent lithium oxide at Finniss, Liberia launched its Limec 2026 investment conference, and a Peabody evacuation order recirculating today dates from July, not this week.
The first 40 million US dollars of Glencore funding for Orion Minerals' Prieska copper zinc mine in South Africa's Northern Cape is now unconditional, clearing development of the Uppers mine to start with first drawdown expected by the end of October.
Ghana's lands minister says District Mining Committees will begin issuing mining licences locally under the new Minerals and Mining Act, ending the requirement to pursue licences through Accra, as cooperative mining societies replace illegal galamsey workings.
Fortescue has sold more than 40 tonnes of copper concentrate cleaned by its Toowong arsenic removal process, cutting arsenic from up to 7 percent in feedstock to below 0.25 percent while retaining more than 99.9 percent of the copper.
Cobalt Blue Holdings has signed a non-binding term sheet with Swiss trader STG Metals for the sale of standard grade cobalt rounds from its planned Kwinana Cobalt Refinery in Western Australia, a project of about 3,000 tonnes of cobalt a year.
CME Group will launch financially settled tungsten futures on COMEX by early in the first quarter of 2027, giving a market worth more than 20 billion dollars its first exchange traded forward price.
China's primary aluminium production reached a record 11.84 million tonnes in the third quarter, up 2.2 percent year on year, with September output of 3.91 million tonnes, official data showed on Monday.
Infrastructure
Applied Blockchain Inc's 2.75% notes due 2030, CUSIP 038169AB4, printed at 212.59 at 11:11:24 ET on 2026-10-19, down from a previous print of 242.44 and 29.85 points below the reference of 242.44.
IREN Ltd's 3.25% notes due 2030, CUSIP 46270CAB5, printed at 187.5 at 10:45:38 ET on 2026-10-19, down from a previous print of 196.74 and 76 points below the reference of 263.5.
CoreWeave Inc's bond, CUSIP 21873SAD0, printed at 79.6097 at 10:01:29 ET on 2026-10-19, down from a previous print of 84.0 and 14.62 points below its latest fund mark.
KKR has agreed to sell Infinity Transportation, the railcar and intermodal equipment lessor with about 50,000 railcars, to Ares Infrastructure Equity and Ares Insurance Solutions funds for an enterprise value of about 2.9 billion dollars.
Dangote Petroleum Refinery said its ongoing initial public offering has drawn subscriptions from more than 90 countries, including 51 of Africa's 54 nations, and reported nine-month revenue of 22.5 billion dollars and net profit of 4.7 billion dollars ahead of the offer's October 27 close.
Tanzania's Amsons Group has agreed to acquire Geneva-based Oryx Energies' downstream oil business in Tanzania, including its service stations, storage terminals and distribution network, in a transaction valued at more than 230 million dollars, lifting its fuel storage capacity from 300,000 to 800,000 metric tonnes.
Primary Health Properties has agreed a 50-50 joint venture with Singapore's GIC, seeded with 27 private hospitals valued at about 700 million pounds, and expects about 500 million pounds of net proceeds.
MSC has been confirmed as joint buyer with Rheinmetall of Romania's bankrupt Mangalia shipyard for 138 million euros, in a deal expected to close within weeks.
France's Epyr raised 15 million euros for industrial heat storage, the Dangote refinery listing drew interest from 90 countries, and sponsor add-on deals ran from Dutch content software to South African seaweed inputs.
The EU LIFE programme has awarded 390 million euros to 135 climate, nature, circular economy and clean energy projects, mobilising total investment of 579 million euros.
EMK Capital has closed a 1.25 billion euro single-asset continuation fund for Dutch installation group VDK Groep, co-led by LGT Capital Partners and Coller EQT.
Egypt's regulator has approved the prospectus for selling 30 percent of state-owned Banque du Caire, up to 4.575 billion shares worth as much as 24.25 billion Egyptian pounds.
The European Commission has selected 77 net-zero technology projects for 3.4 billion euros of Innovation Fund support, financed from Emissions Trading System revenues.
Ares infrastructure equity funds have acquired a significant minority stake in Statera Energy's operational UK storage and flexible generation portfolio of about 1.9 gigawatts.
Politics
The European Commission has signed an association agreement with Andorra and San Marino giving both access to the EU internal market under common rules, alongside updated monetary agreements on their use of the euro.
Mexican protesters demanding clean water forced their way into a state congress, the UN set out the aim of its Haiti sanctions as cutting gang ammunition supplies, and biodiversity talks opened in Armenia.
China's commerce ministry and eight other departments jointly published an opinion on accelerating technology-driven commerce on October 19, the first comprehensive document under that theme, covering goods, services, distribution and future retail scenarios.
Arab party leaders are urging Israel's 21 percent Arab minority to vote in large numbers on October 27, with polls projecting the anti-Netanyahu bloc of Gadi Eisenkot at 52 of 120 Knesset seats and Netanyahu's bloc at 50, short of a majority without Arab support.
Albertans are voting today, with polls open from 9 a.m. to 8 p.m. Mountain Time, on ten referendum questions, the last of which asks whether the province should remain in Canada or begin the legal process toward a binding separation referendum.
Rates
The People's Bank of China issued a joint departmental notice whose full text was not readable in this run, Dubai's economy reached 129 billion dollars in the first half, and a report said the Bank of England is examining Barclays over private credit loans.
The Association of Banks of Paraguay on Sunday asked the Central Bank of Paraguay to publish the solvency position of every lender that received facilities in merger processes, days after senators from the ruling party and the opposition called on President Santiago Pena to remove the central bank's leadership, MercoPress reported.
Food inflation in September ranged from 34.4 percent in Lagos and 33.79 percent in Imo to a decline of 7.47 percent in Taraba and 2.18 percent in Borno, the National Bureau of Statistics said, against a national food rate of 19.59 percent and headline inflation of 14.63 percent.
New Zealand's September quarter consumer price index, due October 22, is forecast by banks between 3.7 and 4.0 percent annually against the Reserve Bank's 3.9 percent projection, with markets pricing roughly an 80 percent chance of a rate increase at the meeting that follows, according to bank previews.
Japan sold one-year treasury discount bills, issue 1414, at a lowest accepted yield of 1.6322 percent and a weighted average yield of 1.6229 percent on Monday, drawing 7,605.0 billion yen of competitive bids for 1,686.7 billion yen accepted, the Ministry of Finance said.
India's conversion auction on Monday accepted 11,302.18 crore rupees of source securities against 20,000 crore notified, switching holders into destination bonds maturing from 2033 to 2060 at cut-off yields between 7.3590 and 7.8391 percent, the Reserve Bank of India said.
Ghana's average bank lending rate fell to 15.9 percent in August 2026 from 24.2 percent a year earlier, and the interbank weighted average rate fell to 10.2 percent from 23.3 percent, as the Bank of Ghana's cut in its policy rate to 14.0 percent from 25.0 percent passed through the system, the central bank said.
Ghana's treasury bill auction drew 5.173 billion cedis of bids against a 5.019 billion target and accepted 3.481 billion, with the 91-day yield up 2 basis points to 4.62 percent and the 364-day yield down 4 basis points to 9.71 percent, MyJoyOnline reported from Bank of Ghana results.
Post-crisis regulation costs euro area banks about 35 basis points to lend unsecured in money markets and about 15 basis points to borrow, against typically well below 10 basis points for repo backed by high-quality collateral, an ECB occasional paper published on Monday estimates.
All 22 market participants in a Reuters survey expect China to leave the one-year loan prime rate at 3.00 percent and the five-year rate at 3.50 percent on Tuesday, a seventeenth straight month on hold, after third quarter growth beat expectations.
Canada publishes September consumer prices and the Bank of Canada's third quarter Business Outlook Survey and Canadian Survey of Consumer Expectations on Monday, the last major evidence before the bank's October 28 decision and its promised significant upward revision to the inflation forecast.
Indian states accepted 23,016.418 crore rupees of the 24,400 crore notified in Monday's state government securities auction, after Andhra Pradesh accepted nothing on its 1,000 crore reissue and Punjab took only part of its 2035 line, the Reserve Bank of India said.
Technology
Frontier has signed an 11.7 million dollar carbon removal deal with 44.01 for 20,932 tons, Khosla Ventures has led a 50 million dollar round for India's Even Healthcare at a 300 million dollar valuation, and time standards bodies have voted to abolish leap seconds.
Replit chief executive Amjad Masad said the AI coding platform is no longer working with Anthropic as its partner and has made OpenAI's ChatGPT its default, citing cost, partnership and benchmark performance, while clarifying that customers can still choose Claude models.
A Linux flaw tracked as CVE-2026-99999 and rated 9.3, now named PwnEscape, lets a guest virtual machine escape to its host using malformed IPv4 packets, with an upstream kernel fix already moving into major distributions.
Hillwood Polska has reduced the size of its planned 130 megawatt data center campus at Reguly, southwest of Warsaw, and moved the buildings further from homes, after residents objected over water, electricity and noise.
GreenSquare has opened the first phase of its SYD1 campus in western Sydney, a reused 1995 IBM data center now hosting about 8,200 Nvidia Blackwell Ultra GPUs for Australian AI cloud firm Sharon AI, with an 80 megawatt expansion planned.
Disney has agreed to offer jobs to at least 60 Character.AI employees, the majority of its workforce, at an estimated 60 million dollars in annual compensation, after the chatbot startup filed for bankruptcy, a legal filing reported by Bloomberg and TechCrunch shows.
The UK Court of Appeal has refused Microsoft permission to appeal to the Supreme Court in its long running dispute with ValueLicensing over reselling pre-owned software licenses, leaving a November 2025 ruling for ValueLicensing in place.
ConnectWise has suspended its Cloud Backup, SaaS Security and Cloud Management services after detecting unauthorized access to application identities on October 15, leaving managed service providers unable to back up or restore customer data while the investigation continues.
Life Sciences
Hansoh Pharmaceutical units have entered a partnership and licensing deal with Roche covering a portfolio of antibody drug conjugate programs, worth potentially more than 15 billion dollars, with 400 million dollars paid upfront.
UK regulators have opened a consultation on schools holding adrenaline nasal sprays, Zealand Pharma cleared a Phase 1 safety readout for its Kv1.3 blocker, and Roche previews a three program ESMO data package led by its KRAS drug divarasib.
OSE Immunotherapeutics' cancer vaccine Tedopi, combined with docetaxel or nivolumab, produced one year overall survival of 47 percent and 46 percent against 29 percent for docetaxel alone in the Phase 2 Combi-TED trial in second line metastatic lung cancer.
Veradermics' extended release oral minoxidil VDPHL01 met all primary and secondary endpoints in the 536 man Phase 3 Study 304 in male pattern hair loss, with no treatment related serious adverse events and no cardiac events of special interest.
California's Proposition 38, an $8.4 billion bond for immunology research on the November 3 ballot, has divided the field's top US association, STAT reported, because half the money is reserved for a single UC affiliated institute matching criteria tied to the measure's main funder.
The FDA has approved a once daily autoinjector for UCB's Zilbrysq (zilucoplan), giving adults with anti AChR antibody positive generalised myasthenia gravis a second self administration option, with complete dose delivery in 99.8 percent of 449 autoinjector uses.
GSK's B7-H3 antibody drug conjugate risvutatug rezetecan produced a confirmed objective response rate of 61 percent at the 8 mg/kg dose in relapsed extensive stage small cell lung cancer, against 32 percent at 6 mg/kg, in the first global data from the EMBOLD PanTumour-101 trial.
Gilead's oral pill emvistegrast produced a 23 percent placebo adjusted clinical remission rate at 12 weeks in moderate to severe ulcerative colitis, a statistically significant Phase 2 result that STAT reported beat Wall Street expectations.
Treating ulcerative colitis patients to full disease clearance with Takeda's Entyvio, rather than symptom remission alone, cut the risk of a first disease related complication by nearly 70 percent (hazard ratio 0.33, p=0.0014) in the Phase 4 VERDICT trial.
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