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Friday, October 16, 2026

City Therapeutics prices upsized 230 million dollar IPO

Life Sciences Friday, October 16, 2026 · Updated Oct 16, 2026 07:07

City Therapeutics priced an upsized initial public offering of 10,952,381 shares at 21 dollars each, raising about 230 million dollars gross, and starts trading on Nasdaq today under the ticker CTY.

Why it matters: An upsized pricing is the biotech IPO market's clearest health signal this autumn: investors paid up for an RNAi platform story, and the deal gives the sector a pricing reference for the queue behind it.

Data as of Pricing announced October 15, 2026; trading expected October 16, closing expected October 16, 2026 (SEC prospectus, Form 424B5; Endpoints News; BioPharma Dive). Early headlines citing a 200 million dollar deal predate the upsizing.

City Therapeutics has priced its initial public offering at 21 dollars a share, selling 10,952,381 shares for gross proceeds of about 230 million dollars, above the roughly 200 million dollars the deal was first reported at. The shares are due to start trading on Nasdaq today under the ticker CTY, with the offering expected to close today. BofA Securities and Jefferies led the deal, with Leerink Partners and Piper Sandler as bookrunners on the prospectus.

City is an RNA interference company built by veterans of Alnylam, the field’s founding company, and its pitch is a next generation RNAi platform aimed first at rare diseases, led by a candidate for thrombosis prevention. RNAi, silencing a gene by destroying its messenger RNA, is one of the few platform technologies with multiple approved products and a manufacturing playbook investors understand.

That is why the upsizing matters beyond one company. Biotech IPOs have been selective all year, pricing only where a platform has human data or a clear regulatory path. A deal that grows by 15 percent at pricing, led by bulge bracket banks, tells the dozens of private companies in the queue that the window is open for quality, at a price.

Sources

  1. Next-gen RNAi drugmaker City prices $200M IPO · BioPharma Dive · 2026-10-16
  2. Next-gen RNAi drugmaker City prices $200M IPO · BioPharma Dive · 2026-10-16